His overall record of five wins, two draws and seven defeats included shock losses to Hapoel Beer Sheva and Sparta Prague in the Europa League and at home to Cagliari in Serie A.
Media reports said former England manager Roy Hodgson was in line to replace De Boer at Selhurst Park.
A summary of Friday's action in the FIFA World Cup 2026 UEFA Qualifiers.
Inter Milan have appointed former Ajax Amsterdam manager Frank de Boer as their new head coach on a three-year contract replacing Roberto Mancini.
Arne Slot is the first to win the top flight in England where many of his compatriots have suffered dents to their reputations over the years.
The Dutch captain, 34, has won a Dutch record of 112 caps and had said he would retire after the tournament.
Frank de Boer ruled out accepting the Tottenham Hotspur job again on Friday, saying he was satisfied with his post at Ajax Amsterdam.
The veteran defender is set to make his 111th appearance for the Netherlands on Wednesday.
De Boer, who lasted only 77 days as Crystal Palace manager after losing his first four league games in charge with no goals scored, said in an interview on BT Sport that it was "a pity" Mourinho was Rashford's manager because he was not getting enough chances.
Missing out on the last Euros in France and then the 2018 World Cup in Russia were a major setback and re-establishing their reputation as a footballing force is top priority for coach Frank de Boer and his team.
Midfielder Donny van de Beek has had to pull out of the Netherlands squad for the European Championship because of injury.
The identity of the Netherlands goalkeeper for their opening World Cup match remains a closely guarded secret
Spurs striker Bergwijn is major casualty as Netherlands trim squad
The 71-year-old, who has battled with cancer over the last year, concluded his third spell as the Netherlands coach with their penalty shootout loss and will be replaced by Ronald Koeman.
It will also come in front of 5,000 spectators who are being allowed into Saturday's game at the Amsterdam Arena.
With the club football season over, and the World Cup only a couple of weeks away, rediff.com takes stock of how some of the top coaches in European football performed in their first season in charge.
De Jong is proud to join the likes of compatriots Ronald Koeman, Frank de Boer and Patrick Kluivert in heading to the Nou Camp, having dreamed of wearing Barca colours.
Goals from Freddie Hinds, Bobby Reid and Niclas Eliasson put the visitors through to the third round. Watford finished with 10 men after Jose Holebas was sent off.
Bayern Munich will be without experienced Franck Ribery when they meet Manchester City in their Champions League Group E opener on Wednesday with fellow winger Arjen Robben also doubtful, coach Pep Guardiola said.
The Dutch were 2-0 up with 15 minutes left in the Euro 2020 match, only to allow their opponents two quick goals and the chance to share the points before Dumfries headed home a dramatic winner to the delight of the home fans.
Ajax Amsterdam scored after 72 seconds and added a second goal near the end to inflict a 2-0 home defeat on champions PSV Eindhoven and take over the lead of the Dutch league.
Images from the English Premier League matches played on Sunday
Juventus coach Massimiliano Allegri criticised his players for letting their guard down and losing 2-1 at arch-rivals Inter Milan after taking the lead in the second half at the San Siro.
Paul Pogba repaid some of his world record transfer fee with two goals as Manchester United rediscovered their early-season shine, cruising to a 4-1 Europa League win over Fenerbahce to go top of their group on Thursday. Pogba scored a penalty and rifled United's third into the top corner. Anthony Martial also netted from the spot and Jesse Lingard fired home in the second half before former Old Trafford favourite Robin van Persie pulled one back for Fenerbahce. Inter Milan and AS Roma, though, had more testing evenings. Coach Frank de Boer breathed a sigh of relief when Inter survived an onslaught from Southampton to end a three-match losing streak with a 1-0 victory while Roma conceded twice late on to draw 3-3 at home to Austria Vienna.
Holders France got their World Cup qualifying campaign off to a disappointing start with a 1-1 draw at home to Ukraine
The Euro 2020 Championship is being held across Europe for the first time in the competition's 60-year history, with 11 host cities in total.
A factbox on new Manchester United manager Louis van Gaal.
A makeshift England side beat Romania 1-0 in their final Euro 2020 warm-up game, while Belgium's Romelu Lukaku underlined his status as one of the world's top strikers with his 60th international goal to secure a 1-0 win over Croatia.
Louis van Gaal has said he would consider joining Tottenham Hotspur once his contract with the Dutch national team finishes after this year's World Cup in Brazil.
More clubs should follow the Ajax Amsterdam model of promoting former players to executive roles, according to the Dutch side's assistant manager Dennis Bergkamp.
Veteran Francesco Totti scored a stoppage-time winner from a penalty in his first appearance of the season as Roma beat Sampdoria 3-2 in Serie A on Sunday. The 39-year-old former Italy international has now scored in 23 consecutive league seasons for Roma. Sunday's goal lifted the team to within two points of early leaders Juventus, who defeated Sassuolo 3-1 on Saturday.
Mauricio Pinilla converted a late penalty to give Atalanta a 2-1 win over Inter Milan and condemn their troubled opponents to a third successive Serie A defeat on Sunday.
AC Milan surged into third place in Serie A with a 3-1 win at Chievo Verona on Sunday but their great city rivals Inter Milan were left in turmoil as their captain Mauro Icardi again came under fire from his own fans in the 2-1 defeat by Cagliari.
Miralem Pjanic's free kick gave Juventus a 2-1 win at Chievo on Sunday as goalkeeper Gianluigi Buffon celebrated his 600th Serie A appearance.
Swedish striker Zlatan Ibrahimovic returned to Manchester United on a year-year contract "to finish what I started," the 35-year-old announced in a club statement on Thursday.
AC Milan have made a habit of muddling through under coach Massimiliano Allegri and they did it again on Wednesday by scraping into the Champions League knockout stage with a performance which left opponents Ajax Amsterdam fuming.
Images from the World Cup qualifying matches played on Monday.
Marcus Rashford's penalty and a deflected strike from Mason Mount helped England come from a goal down to overcome top-ranked Belgium 2-1 at Wembley on Sunday and climb above them in their UEFA Nations League group.
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